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Cake day: June 25th, 2023

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  • First, make sure you’re never alone with her. It’s important to have someone be able to vouch for you that nothing bad happened. Even if it’s not her intention, rumors spread and mutate in the most unexpected ways, and you’ll want to make sure you’re in the clear if it ever comes to pass that people start to suspect that you are having a relationship with her.

    Second, you’ll want to speak with her. Make it clear that you are serious and that this is a serious talk. Whenever you see her next, just say something like “we need to have a talk.” Might be cliche, but the cliche aspect of it reinforces the serious nature of it IMO, since most people already associate that phrase with something serious.

    You don’t need to be rude, but you need to be very clear where you stand on the matter. Make it clear that 1) you are not in a relationship with her, 2) you do not wish to be in a relationship with her, 3) you don’t appreciate her saying that you’re in a relationship with her. With talks of this nature, there’s no point beating around the bush. She may be temporarily hurt, but there is a difference between being hurt due to rejection and hurt due to injustice. She will come to appreciate the honesty in time.






  • It should also be mentioned that the two methods aren’t mutually exclusive, and there’s a ton of synergy between using the old ways (x-ray crystallography and cryo-em) and using the new way (AlphaFold). Because even when you measure the protein structure, the old ways only tell you the shape of the protein but not the skeletal structure of the protein (which is the actual important part), so to my knowledge, there’s a bit of finicking around to figure out how the protein folds into that shape. AlphaFold predicts how the protein folds, so you can cross reference that with the measured shape of the protein to better estimate where the protein skeleton is in the measured shape



  • Not entirely true. Vaccines induce the adaptive immune system, which is slow but precise. Getting sick for real induces the innate immune system, which is god awful and you should not be relying on it. S. pneumoniae causes pneumonia because the innate immune system goes overdrive and kills you before it kills the bacteria. COVID-19 induces cell-innate inflammasome activation and leads to a cytokine storm, which then leads to even more damage to the lungs as the immune cells come in. Both diseases have effective vaccines that do not do anything close to this.

    Deadly diseases tend to be deadly not because of the microbe itself, but because the innate immune system overreacts and kills you in the process of fighting off the disease.

    Getting vaccinated diminishes the role that the innate immune system plays when you get sick, since the B cells responsible for producing antibodies for the disease are already mature. Having available antibodies also allows the immune system to rely on the complement system, which allows it to detect and kill invading microbes way earlier than otherwise.



  • Contramuffin@lemmy.worldtoAsklemmy@lemmy.mlQuestion about instances
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    4 months ago

    Lemmy.world, by political ideology, is most similar to old Reddit. Namely, you’re most likely going to find generally-left-of-center people. Several other instances (namely lemmy.ml) are known for being significantly more left-leaning, basically hard communist.

    As is tradition for left-leaning people, there’s a lot of infighting. .world people think that .ml people are tankies. .ml people think that .world people are corporate bootlickers. Both sides accuse the other of heavy-handed censorship.

    Basically, I wouldn’t worry about it. It’s just your standard leftism infighting.


  • To give more detail: Proton uses a hacky workaround called fsync. Fsync was developed by the Wine developers but was explicitly not merged into Wine because, by their own admission, this is a really hacky workaround and it’s definitely not the right way of doing things.

    For games, using fsync is far better than not using anything, and so Proton uses fsync. Apparently there’s recently been concern that the fsync workaround is going to become a bottleneck in modern games (not entirely sure the reasoning why), and so the Wine developers pushed for the development of NTsync, which is basically fsync if it weren’t a hacky workaround. NTsync alleviates the bottleneck that fsync creates, making it more robust, less hacky, and more futureproof.

    In short, don’t expect any noticeable performance increases, but Proton might work more consistently and it might improve performance for future games



  • Whether or not I like him is irrelevant to the point at hand, but since the topic is now brought up, I should point out that I don’t watch LTT.

    The bigger point here is that a major tech channel with a huge audience seems to be pushing for Linux adoption to a novel audience (having Linux content geared towards Linux enthusiasts does not bring in new users), and a direct consequence of that is that we should 1. expect to welcome an influx of new users to the Linux ecosystem, along with all of the consequences that that entails and 2. acknowledge this video as a symbol of increasing Linux acceptance among mainstream users. The particular channel is itself irrelevant, compared to the bigger fact that such a video was even made at all.

    To use your example, it would be like if we were a community of used bathwater enthusiasts and we decided to bury any news about that influencer selling her bathwater.


  • On the contrary, if someone is able to shoot themselves in the foot and there is a sizeable portion of people who don’t immediately think that that person is a bumbling idiot, then things can and should improve from a technological standpoint.

    The kind-of-techy gaming crowd is exactly the audience that needs to be targetted for continued improvement of the Linux ecosystem, both because they are the most adjacent to the current target audience and because a not-insignificant portion of them actively dislike Windows and wants an alternative. And if they see that Linus runs into an error and thinks that they might come across a similar error, then that is, in fact, a disservice to the Linux ecosystem that needs to be addressed. It doesn’t matter if Linus did it intentionally or not - the fact that many of his viewers think it to be genuine is proof enough that there needs to be more polish.

    On a more personal level, I can tell you that that your sort of outlook directly hindered my adoption of Linux. I was part of that exact kind-of-techy gaming crowd at one point, and it took me multiple attempts across almost a decade to really take a substantial leap towards Linux. And throughout all of my previous attempts, the one reason that kept me from adopting Linux earlier was the unshakeable feeling that Linux was made for people who already knew what they were doing, and everyone else gets tossed to the wayside.

    That’s what Valve understood when they made their Steam deck, and as a direct consequence of that understanding, many of the kind-of-techy gaming crowd want a public release of SteamOS over a much more established Linux distro. And for what it’s worth, Linus seems generally positive towards Linux in this particular video, and my interpretation is that his channel will begin to convince more of his audience to try out Linux in the coming months. If nothing else, then it seems worth celebrating that Linux is being talked about in a positive way on a more mainstream channel.